Huntington s disease is an example of a rare disease which are also referred to as rare and intractable diseases or orphan diseases and are defined as affecting fewer than 20 000 people in korea korean centers for disease control and prevention 2006 the korean national health insurance nhi is a quasi governmental organization
Extreme cold health problems like skin cancer in frostbite scars or pain tingling or numbness in the fingers and toes caused by the effects of cold climates you re at higher risk if you served in the chosin reservoir campaign conducted from october through december 1950 in extreme subzero temperatures occupational job related
In an effort to enhance clinical practice and bolster the medical support system for hd in south korea the korean huntington s disease society khds was established in july 2022 this development occurred approximately two years after the initiation of the first korean huntington s disease cohort khdc study a total of 13 centers were
Huntington 39 s disease causes nerve cells in the brain to decay over time the disease affects a person 39 s movements thinking ability and mental health huntington 39 s disease is rare it 39 s often passed down through a changed gene from a parent huntington 39 s disease symptoms can develop at any time but they often begin when people are in their 30s
The european huntington 39 s disease network ehdn commissioned an international task force to provide global evidence based recommendations for everyday clinical practice for treatment of huntington 39 s disease hd the objectives of such guidelines are to standardize pharmacological surgical and non pharmacological treatment regimen and improve
Huntington 39 s disease hd also known as huntington 39 s chorea is an incurable neurodegenerative disease 7 that is mostly inherited 8 the earliest symptoms are often subtle problems with mood or mental psychiatric abilities 9 1 a general lack of coordination and an unsteady gait often follow 2 it is also a basal ganglia disease
Cal support system for hd in south korea the korean hunting ton s disease society khds was established in july 2022 this development occurred approximately two years after the initia tion of the first korean huntington s disease cohort khdc study 6 a total of 13 centers were involved in constructing the ini tial cohort
A practical guide for clinical approach to patients with huntington 39 s disease in korea a practical guide for clinical approach to patients with huntington 39 s disease in korea j mov disord 2024 apr 17 2 138 149 doi 10 14802 jmd 24040
A novel gene containing a trinucleotide repeat that is expanded and unstable on huntington 39 s disease chromosomes the huntington 39 s disease collaborative research group cell 1993 mar 26 72 6 971 83 doi 10 1016 0092 8674 93 90585 e kremer b almqvist e theilmann j spence n telenius h goldberg yp hayden mr sex dependent mechanisms for
Abstract objective huntington 39 s disease hd is a rare neurological disorder and its current status in korea is not well investigated this study aims to determine the prevalence and incidence of hd and to investigate the clinical features of hd patients in korea methods we estimated the crude prevalence and annual incidence of hd based on
Methods from 1994 to 2011 thirty six subjects were diagnosed as hd in seoul national university hospital demographic clinical and genetic data were carefully analyzed in all subjects results mean age of onset was 46 5 12 7 years and mean expanded cag repeat size was 45 4 4 7 twenty eight subjects 80 had a family history of hd
This is the first study to estimate the prevalence and incidence of hd in korea and the largest hd series in the asian population and its analyses might be useful for further studies and large scale investigations in hd patients objective huntington s disease hd is a rare neurological disorder and its current status in korea is not well investigated this study aims to determine the
The survival of huntington s disease hd patients is reported to be 15 20 years however most studies on the survival of hd have been conducted in patients without genetic confirmation with the possible inclusion of non hd patients and all studies have been conducted in western countries the survival of patients with hd in east asia
Huntington 39 s disease hd is a rare neurological disorder and its current status in korea is not well investigated this study aims to determine the prevalence and incidence of hd and to
Objective this study aimed to develop a korean version of the huntington s disease hd quality of life battery for carers k hdqol c to assess disease related burden in korean caregivers of hd patients and validate the scale background caregivers of hd often face burnout due to the burden of managing the motor cognitive and psychiatric symptoms of
Objective to investigate the genetic characteristics and long term outcome of korean patients with huntington s disease background huntington s disease is an autosomal dominant neurodegenerative disease which results from abnormal expansion of cag triplets huntington s disease presents with motor symptoms of chorea and other abnormal involuntary movements and non motor symptoms of
Background and purpose this study aimed to determine the updated 10 year prevalence of huntington 39 s disease hd in south korea and the medical and economic burdens across the duration of the disease methods data from the national health insurance database during 2010 2019 were analyzed we identified hd cases using predefined criteria
Huntington 39 s disease is a dominantly inherited neurodegenerative disease and is caused by a mutation in a protein called 39 huntingtin 39 which adds a distinctive feature of an expanded stretch of
Huntington s disease hd is an autosomal dominant and intractable neurodegenerative disorder caused by abnormal cytosine adenine guanine cag expansion in the huntingtin gene htt the number of cag repeats n in cag n is the strongest predictor of hd and clinical manifestation appears in individuals with 36 repeats in
Keywordsuntington s disease epidemiology health insurance and review assessment h medical expenditure increased 10 year prevalence of huntington s disease in south korea an analysis of medical expenditure through the national healthcare system introduction huntington s disease hd is an autosomal dominant and intractable
Huntington s disease hd is a rare disease with an annual incidence of 0 29 per 100 000 people and a 10 year prevalence of 2 2 per 100 000 people reported by a recent korean study although it is rare hd has a great medical impact because the disease shows full penetrance among family members and anticipation leading to earlier disease
Increased rates of parkinson s disease have been observed in farmers exposed to 2 4 d or 2 4 5 t and vietnam war veterans exposed to agent orange 20 30 furthermore recent studies in immature cns derived human neuronal cells showed that short term exposures to 2 4 d or 2 4 5 t differentially produce neurotoxic and early degenerative
This study aimed to determine the updated 10 year prevalence of huntington 39 s disease hd in south korea and the medical and economic burdens across the duration of the disease data from the national health insurance database during 2010 2019 were analyzed we identified hd cases using predefined criteria
Objective this is the first prospective cohort study of huntington 39 s disease hd in korea this study aimed to investigate the caregiver burden in relation to the characteristics of patients and caregivers methods from august 2020 to february 2022 we enrolled patients with hd from 13 university hospitals in korea
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